구강설에 발생한 편평상피세포암의 특성과 치료효과

김기호; 최은주; 김형준; 남웅; 차인호

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구강설에 발생한 편평상피세포암의 특성과 치료효과
The characteristics and treatment results of squamous cell carcinomas of oral tongue

대한구강악안면외과학회지 2011년 37권 1호 p.15 ~ 20

김기호, 최은주, 김형준, 남웅, 차인호,

소속 상세정보

김기호 ( Kim Ki-Ho ) - 연세대학교 치과대학 구강악안면외과학교실
최은주 ( Choi Eun-Joo ) - 연세대학교 치과대학 구강악안면외과학교실
김형준 ( Kim Hyung-Jun ) - 연세대학교 치과대학 구강악안면외과학교실
남웅 ( Nam Woong ) - 연세대학교 치과대학 구강악안면외과학교실
차인호 ( Cha In-Ho ) - 연세대학교 치과대학 구강악안면외과학교실

KMID : 0355620110370010015

Abstract

Introduction: The characteristics of oral tongue squamous cell carcinomas (SCC) and the treatment results were reviewed to determine the appropriate treatment strategies.

Materials and Methods : The medical records of 140 patients diagnosed and treated for oral tongue SCC at Yonsei University Health System from January 1995 to December 2004 were reviewed. For statistic analysis, the survival rate was determined using the Kaplan-Meier method with SPSS version 12.0, and the difference in survival rates was evaluated using a log-rank test.

Results: The mean age of the patients with oral tongue SCC patients was 55 (19-85 years old). According to the T, N and pathologic stage, the patients were distributed from a higher to a lower incidence of cases, as follows: T2 (46.4%), T1 (37.9%), T4 (8.5%), and T3 (7.1%); N0 (65%), N1 (20.7%), N2 (13.6%), and N3 (0.7%); and stage Ⅰ (31.4%), stage Ⅱ (25.7%), stage Ⅳ (22.2%), and stage Ⅲ (20.7%). Local and regional recurrence and distant metastasis was present in 13.6%, 5% and 4.2% of patients, respectively. The five-year survival rate was 72.2%, and the prognostic factors for oral tongue SCC included neck metastasis, pathologic stage of the disease, cell differentiation, treatment modality, neck dissection as part of the treatment plan, and neck node recurrence.

Conclusion: It is suggested that ipsilateral neck dissection or bilateral neck dissection should be selected as a treatment of tongue SCC patients with advanced stage.